• Target：
• ALDH3A1

• Fields：
• >>Glycolysis / Gluconeogenesis;>>Histidine metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>beta-Alanine metabolism;>>Metabolism of xenobiotics by cytochrome P450;>>Drug metabolism - cytochrome P450;>>Metabolic pathways

• Gene Name：
• ALDH3A1

• Protein Name：
• Aldehyde dehydrogenase dimeric NADP-preferring

• Human Gene Id：
• 218

• Human Swiss Prot No：
• P30838

• Mouse Swiss Prot No：
• P47739

• Rat Gene Id：
• 25375

• Rat Swiss Prot No：
• P11883

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human ALDH3A1. AA range:236-285

• Specificity：
• ALDH3A1 Polyclonal Antibody detects endogenous levels of ALDH3A1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ALDH3A1;ALDH3;Aldehyde dehydrogenase, dimeric NADP-preferring;ALDHIII;Aldehyde dehydrogenase 3;Aldehyde dehydrogenase family 3 member A1

• Observed Band(KD)：
• 50kD

• Background：
• Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008],

• Function：
• catalytic activity:An aldehyde + NAD(P)(+) + H(2)O = an acid + NAD(P)H.,function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homodimer.,tissue specificity:High levels in stomach, esophagus and lung; low level in the liver and kidney.,

• Subcellular Location：
• Cytoplasm .

• Expression：
• High levels in stomach, esophagus and lung; low level in the liver and kidney.

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