• Target：
• USP19

• Gene Name：
• USP19

• Protein Name：
• Ubiquitin carboxyl-terminal hydrolase 19

• Human Gene Id：
• 10869

• Human Swiss Prot No：
• O94966

• Mouse Gene Id：
• 71472

• Mouse Swiss Prot No：
• Q3UJD6

• Rat Gene Id：
• 361190

• Rat Swiss Prot No：
• Q6J1Y9

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human USP19. AA range:391-440

• Specificity：
• USP19 Polyclonal Antibody detects endogenous levels of USP19 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• USP19;KIAA0891;ZMYND9;Ubiquitin carboxyl-terminal hydrolase 19;Deubiquitinating enzyme 19;Ubiquitin thioesterase 19;Ubiquitin-specific-processing protease 19;Zinc finger MYND domain-containing protein 9

• Observed Band(KD)：
• 130kD

• Background：
• catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 2 CS domains.,

• Function：
• catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 MYND-type zinc finger.,similarity:Contains 2 CS domains.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Single-pass membrane protein .

• Expression：
• Brain,Epithelium,Skin,Testis,

Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses. Science Advances Sci Adv. 2018 May;4(5):eaar2824 WB Human A549 cell

USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy. Cellular & Molecular Immunology Cell Mol Immunol. 2020 Oct;:1-12 WB Human,Mouse HEK293T cell,bone-marrow-derived macrophages (BMDMs)

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