• Target：
• USP15

• Fields：
• >>Mitophagy - animal

• Gene Name：
• USP15

• Protein Name：
• Ubiquitin carboxyl-terminal hydrolase 15

• Human Gene Id：
• 9958

• Human Swiss Prot No：
• Q9Y4E8

• Mouse Gene Id：
• 14479

• Mouse Swiss Prot No：
• Q8R5H1

• Rat Swiss Prot No：
• Q9R085

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human USP15. AA range:81-130

• Specificity：
• USP15 Polyclonal Antibody detects endogenous levels of USP15 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• USP15;KIAA0529;Ubiquitin carboxyl-terminal hydrolase 15;Deubiquitinating enzyme 15;Ubiquitin thioesterase 15;Ubiquitin-specific-processing protease 15;Unph-2;Unph4

• Observed Band(KD)：
• 115kD

• Background：
• This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011],

• Function：
• catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 1 DUSP domain.,tissue specificity:Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.,

• Subcellular Location：
• Cytoplasm . Nucleus . Mitochondrion .

• Expression：
• Expressed in skeletal muscle, kidney, heart, placenta, liver, thymus, lung, and ovary, with little or no expression in other tissues.

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