• Target：
• Smo

• Fields：
• >>Hedgehog signaling pathway;>>Axon guidance;>>Pathways in cancer;>>Proteoglycans in cancer;>>Basal cell carcinoma

• Gene Name：
• SMO

• Protein Name：
• Smoothened homolog

• Human Gene Id：
• 6608

• Human Swiss Prot No：
• Q99835

• Mouse Gene Id：
• 319757

• Mouse Swiss Prot No：
• P56726

• Rat Gene Id：
• 25273

• Rat Swiss Prot No：
• P97698

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SMO. AA range:68-117

• Specificity：
• Smo Polyclonal Antibody detects endogenous levels of Smo protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SMO;SMOH;Smoothened homolog;SMO;Protein Gx

• Observed Band(KD)：
• 86kD

• Background：
• The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010],

• Function：
• disease:Defects in SMO are involved in basal cell carcinoma (BCC).,function:G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO).,similarity:Belongs to the G-protein coupled receptor Fz/Smo family.,similarity:Contains 1 FZ (frizzled) domain.,

• Subcellular Location：
• Membrane ; Multi-pass membrane protein . Cell projection, cilium .

• Expression：
• Brain,Embryonic lung,Synovial membrane,

Sun, Mingjuan, et al. "Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells." Cell & bioscience 6.1 (2016): 44.

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