• Target：
• SENP3

• Gene Name：
• SENP3

• Protein Name：
• Sentrin-specific protease 3

• Human Gene Id：
• 26168

• Human Swiss Prot No：
• Q9H4L4

• Mouse Gene Id：
• 80886

• Mouse Swiss Prot No：
• Q9EP97

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human SENP3. AA range:10-59

• Specificity：
• SENP3 Polyclonal Antibody detects endogenous levels of SENP3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SENP3;SSP3;SUSP3;Sentrin-specific protease 3;SUMO-1-specific protease 3;Sentrin/SUMO-specific protease SENP3

• Observed Band(KD)：
• 80kD

• Background：
• The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP3, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009],

• Function：
• function:Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability.,similarity:Belongs to the peptidase C48 family.,subunit:Binds to UBL1 and SMT3H1.,

• Subcellular Location：
• Nucleus, nucleolus . Nucleus, nucleoplasm . Cytoplasm . Redistributes between the nucleolus and the nucleoplasm in response to mild oxidative stress (PubMed:19680224). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions (By similarity). .

• Expression：
• Epithelium,Lymph,Melanoma,Uterus,

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