• Target：
• NRF-1

• Fields：
• >>Apelin signaling pathway;>>Huntington disease

• Gene Name：
• NRF1

• Protein Name：
• Nuclear respiratory factor 1

• Human Gene Id：
• 4899

• Human Swiss Prot No：
• Q16656

• Mouse Gene Id：
• 18181

• Mouse Swiss Prot No：
• Q9WU00

• Rat Swiss Prot No：
• Q62792

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human NRF1. AA range:221-270

• Specificity：
• NRF-1 Polyclonal Antibody detects endogenous levels of NRF-1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:5000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• NRF1;Nuclear respiratory factor 1;NRF-1;Alpha palindromic-binding protein;Alpha-pal

• Observed Band(KD)：
• 54kD

• Background：
• This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternative splicing results in multiple transcript variants. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1. [provided by RefSeq, May 2014],

• Function：
• function:Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.,PTM:Phosphorylation enhances DNA binding.,similarity:Belongs to the NRF1/Ewg family.,subunit:Homodimer. Binds DNA as a dimer. Interacts with PPRC1.,tissue specificity:Ubiquitously expressed with strongest expression in skeletal muscle.,

• Subcellular Location：
• Nucleus.

• Expression：
• Ubiquitously expressed with strongest expression in skeletal muscle.

Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism. Animals Animals-Basel. 2020 Apr;10(4):560 WB Bovine Liver

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