NF-H Polyclonal Antibody

    • Catalog No.：YT3086
    • Applications：IHC;IF;ELISA
    • Reactivity：Human;Rat;Mouse;
      • Target：
      • NF-H
      • Fields：
      • >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
      • Gene Name：
      • NEFH
      • Protein Name：
      • Neurofilament heavy polypeptide
      • Human Gene Id：
      • 4744
      • Human Swiss Prot No：
      • P12036
      • Mouse Swiss Prot No：
      • P19246
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human NF-H. AA range:923-972
      • Specificity：
      • NF-H Polyclonal Antibody detects endogenous levels of NF-H protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • NEFH;KIAA0845;NFH;Neurofilament heavy polypeptide;NF-H;200 kDa neurofilament protein;Neurofilament triplet H protein
      • Molecular Weight(Da)：
      • 112kD
      • Background：
      • Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008],
      • Function：
      • disease:Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.,function:Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.,online information:ALS genetic mutations db,polymorphism:The number of repeats is shown to vary between 29 and 30.,PTM:Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphor
      • Subcellular Location：
      • Cytoplasm, cytoskeleton . Cell projection, axon .
      • Expression：
      • Brain,Eye,Testis,
      • Products Images
      • Immunohistochemistry analysis of NF-H antibody in paraffin-embedded human lung carcinoma tissue.

      Attributes

      • Code：
      • YT3086
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-07-04
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