• Target：
• MYBPC1

• Gene Name：
• MYBPC1

• Protein Name：
• Myosin-binding protein C slow-type

• Human Gene Id：
• 4604

• Human Swiss Prot No：
• Q00872

• Rat Gene Id：
• 362867

• Rat Swiss Prot No：
• Q63518

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MYBPC1. AA range:218-267

• Specificity：
• MYBPC1 Polyclonal Antibody detects endogenous levels of MYBPC1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MYBPC1;MYBPCS;Myosin-binding protein C; slow-type;Slow MyBP-C;C-protein, skeletal muscle slow isoform

• Observed Band(KD)：
• 120kD

• Background：
• This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

• Function：
• function:Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.,similarity:Belongs to the immunoglobulin superfamily. MyBP family.,similarity:Contains 3 fibronectin type-III domains.,similarity:Contains 7 Ig-like C2-type (immunoglobulin-like) domains.,

• Subcellular Location：
• cytosol,myofibril,myosin filament,

• Expression：
• Brain,Fetal skeletal muscle,Hippocampus,Liver,Muscle pool- 2 tissue

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