• Target：
• MKP-4

• Fields：
• >>MAPK signaling pathway;>>Signaling pathways regulating pluripotency of stem cells

• Gene Name：
• DUSP9

• Protein Name：
• Dual specificity protein phosphatase 9

• Human Gene Id：
• 1852

• Human Swiss Prot No：
• Q99956

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human DUSP9. AA range:151-200

• Specificity：
• MKP-4 Polyclonal Antibody detects endogenous levels of MKP-4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• DUSP9;MKP4;Dual specificity protein phosphatase 9;Mitogen-activated protein kinase phosphatase 4;MAP kinase phosphatase 4;MKP-4

• Observed Band(KD)：
• 42kD

• Background：
• The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progr

• Function：
• catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Inactivates MAP kinases. Has a specificity for the ERK family.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.,similarity:Contains 1 rhodanese domain.,similarity:Contains 1 tyrosine-protein phosphatase domain.,

• Subcellular Location：
• Cytoplasm.

• Expression：
• Kidney,Liver,Lung,Placenta,

MKP-4 suppresses hepatocarcinogenesis by targeting ERK1/2 pathway. Cancer Cell International Cancer Cell Int. 2019 Dec;19(1):1-15 WB,IF Human 1:500,1:500 HCC tissues HepG2 cell,SK-Hep1 cell,LO2 cell,SMMC-7721 cell

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