• Target：
• Cdc5L

• Fields：
• >>Spliceosome

• Gene Name：
• CDC5L

• Protein Name：
• Cell division cycle 5-like protein

• Human Gene Id：
• 988

• Human Swiss Prot No：
• Q99459

• Mouse Gene Id：
• 71702

• Mouse Swiss Prot No：
• Q6A068

• Rat Gene Id：
• 85434

• Rat Swiss Prot No：
• O08837

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human CDC5L. AA range:721-770

• Specificity：
• Cdc5L Polyclonal Antibody detects endogenous levels of Cdc5L protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:5000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• CDC5L;KIAA0432;PCDC5RP;Cell division cycle 5-like protein;Cdc5-like protein;Pombe cdc5-related protein

• Molecular Weight(Da)：
• 92kD

• Background：
• The protein encoded by this gene shares a significant similarity with Schizosaccharomyces pombe cdc5 gene product, which is a cell cycle regulator important for G2/M transition. This protein has been demonstrated to act as a positive regulator of cell cycle G2/M progression. It was also found to be an essential component of a non-snRNA spliceosome, which contains at least five additional protein factors and is required for the second catalytic step of pre-mRNA splicing. [provided by RefSeq, Jul 2008],

• Function：
• disease:A chromosomal aberration involving CDC5L is found in multicystic renal dysplasia. Translocation t(6;19)(p21;q13.1) with USF2.,function:DNA-binding protein involved in cell cycle control. May act as a transcription activator. Also seems to be involved in the second catalytic step of pre-mRNA splicing.,PTM:Phosphorylated; which enhances interaction with PPP1R8.,similarity:Belongs to the CEF1 family.,similarity:Contains 2 HTH myb-type DNA-binding domains.,subcellular location:May shuttle between cytoplasm and nucleus.,subunit:Homodimer. Interacts with DAPK3 (By similarity). Binds to DNA. Binds to adeno-pre-mRNA in an ATP-stimulated manner. Belongs to the spliceosome complex. Part of a spliceosomal 'core' complex consisting of CDC5L, PLRG1, SPF27, CCAP1, CCAP3 and CCAP6. Interacts with PLRG1, Lodestar/TTF2, and NIPP1/PPP1R8. Identified in the spliceosome C complex, at least composed

• Subcellular Location：
• Nucleus . Nucleus speckle . Cytoplasm . May shuttle between cytoplasm and nucleus. .

• Expression：
• Ubiquitously expressed in both fetal and adult tissues.

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