• Target：
• APC1

• Fields：
• >>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection

• Gene Name：
• ANAPC1

• Protein Name：
• Anaphase-promoting complex subunit 1

• Human Gene Id：
• 64682

• Human Swiss Prot No：
• Q9H1A4

• Mouse Gene Id：
• 17222

• Mouse Swiss Prot No：
• P53995

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human APC1. AA range:321-370

• Specificity：
• APC1 Polyclonal Antibody detects endogenous levels of APC1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• ANAPC1;TSG24;Anaphase-promoting complex subunit 1;APC1;Cyclosome subunit 1;Mitotic checkpoint regulator;Testis-specific gene 24 protein

• Molecular Weight(Da)：
• 217kD

• Background：
• This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011],

• Function：
• function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.,similarity:Belongs to the APC1 family.,similarity:Contains 4 PC repeats.,subunit:The APC/C is composed of at least 11 subunits.,

• Subcellular Location：
• nucleoplasm,anaphase-promoting complex,cytosol,

• Expression：
• Colon,Epithelium,Ovary,Placenta,

Lei, Bin, et al. "PRPS2 expression correlates with Sertoli-cell only syndrome and inhibits the apoptosis of TM4 Sertoli cells." The Journal of urology 194.5 (2015): 1491-1497.

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