• Target：
• AP-2γ

• Gene Name：
• TFAP2C

• Protein Name：
• Transcription factor AP-2 gamma

• Human Gene Id：
• 7022

• Human Swiss Prot No：
• Q92754

• Mouse Gene Id：
• 21420

• Mouse Swiss Prot No：
• Q61312

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human AP2C. AA range:401-450

• Specificity：
• AP-2γ Polyclonal Antibody detects endogenous levels of AP-2γ protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TFAP2C;Transcription factor AP-2 gamma;AP2-gamma;Activating enhancer-binding protein 2 gamma;Transcription factor ERF-1

• Observed Band(KD)：
• 45kD

• Background：
• transcription factor AP-2 gamma(TFAP2C) Homo sapiens The protein encoded by this gene is a sequence-specific DNA-binding transcription factor involved in the activation of several developmental genes. The encoded protein can act as either a homodimer or heterodimer with other family members and is induced during retinoic acid-mediated differentiation. It plays a role in the development of the eyes, face, body wall, limbs, and neural tube. [provided by RefSeq, Jul 2008],

• Function：
• domain:The WW-binding motif mediates interaction with WWOX.,function:Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC.,induction:During retinoic acid-mediated differentiation.,online information:Activatin protein 2 entry,PTM:Sumoylated on Lys-10; which inhibits transcriptional activity.,similarity:Belongs to the AP-2 family.,subunit:Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I

• Subcellular Location：
• Nucleus .

• Expression：
• Liver,Mammary tumor,Ovary,Skin,

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