• Target：
• AF-10

• Gene Name：
• MLLT10

• Protein Name：
• Protein AF-10

• Human Gene Id：
• 8028

• Human Swiss Prot No：
• P55197

• Mouse Gene Id：
• 17354

• Mouse Swiss Prot No：
• O54826

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human AF10. AA range:211-260

• Specificity：
• AF-10 Polyclonal Antibody detects endogenous levels of AF-10 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MLLT10;AF10;Protein AF-10;ALL1-fused gene from chromosome 10 protein

• Observed Band(KD)：
• 109kD

• Background：
• myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10(MLLT10) Homo sapiens This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],

• Function：
• disease:A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein.,disease:A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 PHD-type zinc fingers.,tissue specificity:Expressed abundantly in testis.,

• Subcellular Location：
• Nucleus .

• Expression：
• Expressed abundantly in testis.

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