GIT2 (Phospho Tyr592) rabbit pAb

  • Catalog No.：YP1348
  • Applications：WB
  • Reactivity：Human;Rat;Mouse;
    • Target：
    • GIT2
    • Fields：
    • >>Endocytosis;>>Yersinia infection
    • Gene Name：
    • GIT2 KIAA0148
    • Protein Name：
    • GIT2 (Tyr592)
    • Human Gene Id：
    • 9815
    • Human Swiss Prot No：
    • Q14161
    • Mouse Swiss Prot No：
    • Q9JLQ2
    • Immunogen：
    • Synthesized phosho peptide around human GIT2 (Tyr592)
    • Specificity：
    • This antibody detects endogenous levels of Human GIT2 (phospho-Tyr592)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)
    • Observed Band(KD)：
    • 84kD
    • Background：
    • This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G
    • Function：
    • alternative products:Additional isoforms seem to exist,function:GTPase-activating protein for the ADP ribosylation factor family.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 3 ANK repeats.,subunit:Interacts with TGFB1I1 (By similarity). Interacts with G protein-coupled receptor kinases. Associates with paxillin. Also interacts with PIX exchange factors.,
    • Subcellular Location：
    • nucleoplasm,focal adhesion,
    • Expression：
    • B-cell,Bone marrow,Cerebellum,Dermoid cancer,Epithelium,Skin,T-cell,

    Attributes

    • Code：
    • YP1348
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-07-04
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