FoxM1 (Phospho Thr600) rabbit pAb
- Catalog No.:YP1337
- Applications:WB
- Reactivity:Human;Rat;Mouse;
- Target:
- FoxM1
- Fields:
- >>Cellular senescence
- Gene Name:
- FOXM1 FKHL16 HFH11 MPP2 WIN
- Protein Name:
- FoxM1 (Thr600)
- Human Gene Id:
- 2305
- Human Swiss Prot No:
- Q08050
- Mouse Swiss Prot No:
- O08696
- Rat Swiss Prot No:
- P97691
- Immunogen:
- Synthesized phosho peptide around human FoxM1 (Thr600)
- Specificity:
- This antibody detects endogenous levels of Human FoxM1 (phospho-Thr600)
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-2000
- Purification:
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Forkhead box protein M1 (Forkhead-related protein FKHL16) (Hepatocyte nuclear factor 3 forkhead homolog 11) (HFH-11) (HNF-3/fork-head homolog 11) (M-phase phosphoprotein 2) (MPM-2 reactive phosphoprotein 2) (Transcription factor Trident) (Winged-helix factor from INS-1 cells)
- Observed Band(KD):
- 83kD
- Background:
- The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011],
- Function:
- alternative products:Isoform 1 and isoform 2 appear to be the only activators of gene transcription. Isoform 3, found in rat, does not seem to exist in human,developmental stage:Embryonic expression pattern: liver, lung, intestine, kidney, urinary tract; adult expression pattern: intestine, colon, testis and thymus.,domain:Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.,function:Transcriptional activatory factor. May play a role in the control of cell proliferation.,induction:Induced during liver regeneration and oxidative stress.,PTM:Phosphorylated in M (mitotic) phase.,similarity:Contains 1 fork-head DNA-binding domain.,tissue specificity:Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only
- Subcellular Location:
- Nucleus.
- Expression:
- Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
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- Antibody-FAQs
- Products Images
- Western Blot analysis of mouse and rat brain lysis treated or untreated by EGF 20ng/ml 30'.. Primary Antibody was diluted at 1:1000. Secondary antibody(catalog#:RS23920 was diluted at 1:10000