• Target：
• METTL3

• Gene Name：
• METTL3 MTA70

• Protein Name：
• N6-adenosine-methyltransferase 70 kDa subunit (MT-A70) (EC 2.1.1.62) (Methyltransferase-like protein 3)

• Human Gene Id：
• 56339

• Human Swiss Prot No：
• Q86U44

• Mouse Gene Id：
• 56335

• Mouse Swiss Prot No：
• Q8C3P7

• Specificity：
• endogenous

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, rabbit, IgG, Kappa

• Dilution：
• IHC 1:200-400,WB 1:1000-5000,IF 1:200-1000,ELISA 1:5000-20000,IP 1:50-200

• Purification：
• Protein A

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• N6-adenosine-methyltransferase 70 kDa subunit (MT-A70) (EC 2.1.1.62) (Methyltransferase-like protein 3)

• Molecular Weight(Da)：
• 64kD

• Observed Band(KD)：
• 70kD

• Function：
• The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some RNAs and regulates various processes such as the circadian clock, differentiation of embryonic and hematopoietic stem cells, cortical neurogenesis, response to DNA damage, differentiation of T-cells and primary miRNA processing . In the heterodimer formed with METTL14, METTL3 constitutes the catalytic core . N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability, processing, translation efficiency and editing . M6A acts as a key regulator of mRNA stability: methylation is completed upon the release of mRNA into the nucleoplasm and promotes mRNA destabilization and degradation . In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts

• Subcellular Location：
• Nucleus

• Expression：
• Widely expressed at low level. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.

Identification and prediction of molecular subtypes of atherosclerosis based on m6A immune cell infiltration BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS Bowen Xu WB Rat H9c2 cell

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