Uroplakin IIIA (ABT72R) rabbit mAb

  • Catalog No.：YM7228
  • Applications：IHC; WB;; ELISA
  • Reactivity：Human;Mouse;
    • Target：
    • UPK3A
    • Fields：
    • >>Bladder cancer
    • Gene Name：
    • UPK3A
    • Protein Name：
    • Uroplakin-3a (UP3a) (Uroplakin III) (UPIII)
    • Human Gene Id：
    • 7380
    • Human Swiss Prot No：
    • O75631
    • Mouse Swiss Prot No：
    • Q9JKX8
    • Immunogen：
    • Synthesized peptide derived from human protein . at AA range:200-287
    • Specificity：
    • This antibody detects endogenous levels of UPK3A
    • Formulation：
    • PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
    • Source：
    • Monoclonal, Rabbit IgG1, Kappa
    • Dilution：
    • IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
    • Purification：
    • Recombinant Expression and Affinity purified
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • MGC119178；OTTHUMP00000028951；UP III；UP3a；UPIII；UPIIIA；UPK 3；UPK 3A；UPK3；UPK3A；UPK3A_HUMAN；Uroplakin 3A；Uroplakin III；Uroplakin-3a；Uroplakin3A；UroplakinIII
    • Molecular Weight(Da)：
    • 31kD
    • Background：
    • This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],
    • Function：
    • disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation
    • Subcellular Location：
    • Endoplasmic reticulum membrane ; Single-pass type I membrane protein . Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). .
    • Expression：
    • Expressed in ureter.

    Attributes

    • Code：
    • YM7228
    • Size
    • 40μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-07-23
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