• Target：
• PMEL

• Gene Name：
• PMEL

• Protein Name：
• 95 kDa melanocyte specific secreted glycoprotein;95 kDa melanocyte-specific secreted glycoprotein;D12S53E;gp100;M-beta;ME20;ME20 M/ME20 S;ME20-M;ME20-S;ME20M;ME20M/ME20S;ME20S;Melanocyte lineage speci

• Human Swiss Prot No：
• P40967

• Mouse Swiss Prot No：
• Q60696

• Immunogen：
• Synthesized peptide derived from human PMEL AA range:400-500

• Specificity：
• This antibody detects endogenous levels of PMEL

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Monoclonal, Rabbit IgG1, Kappa

• Dilution：
• IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000

• Purification：
• Recombinant Expression and Affinity purified

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• 95 kDa melanocyte specific secreted glycoprotein；95 kDa melanocyte-specific secreted glycoprotein；D12S53E；gp100；M-beta；ME20；ME20 M/ME20 S；ME20-M；ME20-S；ME20M；ME20M/ME20S；ME20S；Melanocyte lineage specific antigen GP100；Melanocyte protein mel 17；Melanocyte protein Pmel 17；Melanocyte protein Pmel 17 precursor；Melanocytes lineage-specific antigen GP100；Melanoma associated ME20 antigen；Melanoma gp100；Melanoma-associated ME20 antigen；Melanosomal matrix protein 17；Melanosomal matrix protein17；P1；p100；p26；PMEL 17；PMEL；PMEL_HUMAN；PMEL17；Premelanosome protein；Secreted melanoma-associated ME20 antigen；SI；SIL；SILV；Silver (Mouse homolog) like；Silver homolog；Silver locus protein homolog；Silver, Mouse, homolog of

• Molecular Weight(Da)：
• 73kD

• Background：
• This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011],

• Function：
• function:Could be a melanogenic enzyme. Could represent an oncofetal self-antigen that is normally expressed at low levels in quiescent adult melanocytes but overexpressed by proliferating neonatal melanocytes and during tumor growth. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.,similarity:Belongs to the Pmel-17/NMB family.,similarity:Contains 1 PKD domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subcellular location:Probably product of proteolytic cleavage.,tissue specificity:Preferentially expressed in melanomas. Some expression was found in dysplastic nevi. Not found in normal tissues nor in carcinomas.,

• Subcellular Location：
• Cytoplasmic

• Expression：
• Skin/ Melanoma

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