• Target：
• CDKN2B

• Gene Name：
• CDKN2B MTS2

• Protein Name：
• Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)

• Human Gene Id：
• 1030

• Human Swiss Prot No：
• P42772

• Mouse Gene Id：
• 12579

• Mouse Swiss Prot No：
• P55271

• Immunogen：
• Synthesized peptide derived from human p15 INK (PTR2192) AA range: 50-138

• Specificity：
• This antibody detects endogenous levels of p15 INK protein.

• Formulation：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• Source：
• Mouse, Monoclonal/IgG

• Dilution：
• WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• Purification：
• Protein G

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Molecular Weight(Da)：
• 15kD

• Observed Band(KD)：
• 15kD

• Background：
• cyclin dependent kinase inhibitor 2B(CDKN2B) Homo sapiens This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008],

• Function：
• Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.

• Subcellular Location：
• Cytoplasmic

• Expression：
• Isoform 2 is expressed in normal (keratinocytes, fibroblasts) and tumor cell lines.

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