• Target：
• HSP 90

• Fields：
• >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

• Gene Name：
• hsp90

• Human Gene Id：
• 3320

• Human Swiss Prot No：
• P07900

• Mouse Swiss Prot No：
• P07901

• Immunogen：
• Purified recombinant human HSP90AA1 protein fragments expressed in E.coli

• Specificity：
• This antibody detects endogenous levels of Hsp90 alpha and Hsp90 beta.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• wb dilution 1:2000

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• D6S182;FLJ26984;FLJ31884;Heat shock 86 kDa;heat shock 90kDa protein 1 alpha;Heat shock protein 90kDa alpha cytosolic class A member 1;Heat shock protein 90kDa alpha cytosolic class B member 1;Heat shock protein HSP 90 alpha;Heat shock protein HSP 90 beta;Heat shock protein HSP 90-alpha;HS90A_HUMAN;HSP 84;HSP 86;Hsp 90;HSP84;HSP86;Hsp89;Hsp90;HSP90 Beta;HSP90A;HSP90AA1;HSP90AB1;HSP90B;HSP90N;HSPC1;HSPC2;HSPCA;HSPCAL1;HSPCAL4;HSPCB;HSPN;LAP2;Lipopolysaccharide associated protein2;LPS associated protein 2;NY REN 38 antigen;Renal carcinoma antigen NY-REN-38.

• Observed Band(KD)：
• 90kD

• Background：
• The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],

• Function：
• caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,

• Subcellular Location：
• Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

• Expression：
• Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius

HSP90 inhibitor AUY922 can reverse Fulvestrant induced feedback reaction in human breast cancer cells. CANCER SCIENCE 2017 May 19 WB Human MCF-7 cell，T47D cell

Mangiferin improves hepatic damage-associated molecular patterns, lipid metabolic disorder and mitochondrial dysfunction in alcohol hepatitis rats. Food & Function Food Funct. 2019 Jun;10(6):3514-3534 IHC Rat Liver, kidney , spleen

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