• Target：
• Fyn

• Fields：
• >>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Axon guidance;>>Osteoclast differentiation;>>Focal adhesion;>>Adherens junction;>>Platelet activation;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>>Fc epsilon RI signaling pathway;>>Cholinergic synapse;>>Prion disease;>>Pathogenic Escherichia coli infection;>>Viral myocarditis

• Gene Name：
• fyn

• Human Gene Id：
• 2534

• Human Swiss Prot No：
• P06241

• Mouse Swiss Prot No：
• P39688

• Immunogen：
• Purified recombinant human Fyn protein fragments expressed in E.coli.

• Specificity：
• This antibody detects endogenous levels of Fyn and does not cross-react with related proteins.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• wb 1:500 icc 1:50

• Purification：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• C syn protooncogene;Fyn;FYN oncogene related to SRC FGR YES;FYN_HUMAN;MGC45350;OKT3 induced calcium influx regulator;P59 FYN;p59-Fyn;Protein tyrosine kinase fyn;Proto oncogene tyrosine protein kinase fyn;Proto-oncogene c-Fyn;Proto-oncogene Syn;Protooncogene Syn;SLK;Src like kinase;Src yes related novel gene;Src-like kinase;Src/yes related novel;Src/yes related novel gene;SYN;Tyrosine kinase p59fyn T;Tyrosine kinase p59fyn(T);Tyrosine-protein kinase Fyn.

• Observed Band(KD)：
• 59kD

• Background：
• This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008],

• Function：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Manganese.,enzyme regulation:Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.,function:Implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1

• Subcellular Location：
• Cytoplasm. Nucleus. Cell membrane. Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.

• Expression：
• Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.

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