RAG-2 Monoclonal Antibody

    • Catalog No.：YM0550
    • Applications：WB;ELISA
    • Reactivity：Human
      • Target：
      • RAG-2
      • Fields：
      • >>FoxO signaling pathway;>>Primary immunodeficiency
      • Gene Name：
      • RAG2
      • Protein Name：
      • V(D)J recombination-activating protein 2
      • Human Gene Id：
      • 5897
      • Human Swiss Prot No：
      • P55895
      • Mouse Swiss Prot No：
      • P21784
      • Immunogen：
      • Purified recombinant fragment of human RAG-2 (350-527aa) expressed in E. Coli.
      • Specificity：
      • RAG-2 Monoclonal Antibody detects endogenous levels of RAG-2 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • RAG2;V(D)J recombination-activating protein 2;RAG-2
      • Molecular Weight(Da)：
      • 59kD
      • References：
      • 1. J Biol Chem. 2004 Sep 10;279(37):38360-8.
        2. Immunity. 2005 Aug;23(2):203-12.
        3. J Clin Invest. 2010 Apr 1;120(4):1337-44. doi: 10.1172/JCI41305.
      • Background：
      • This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodef
      • Function：
      • disease:Defects in RAG2 are a cause of combined cellular and humoral immune defects with granulomas (CHIDG) [MIM:233650]. CHIDG is an immunodeficiency disease with granulomas in the skin, mucous membranes, and internal organs. Other characteristics include hypogammaglobulinemia, a diminished number of T and B cells, and sparse thymic tissue on ultrasonography.,disease:Defects in RAG2 are a cause of Omenn syndrome (OS) [MIM:603554]; a severe immunodeficiency characterized by the presence of activated, anergic, oligoclonal T-cells, hypereosinophilia, and high IgE levels.,disease:Defects in RAG2 are a cause of severe combined immunodeficiency, autosomal recessive T cell-negative, B-cell-negative, NK cell-positive (T(-)B(-)NK(+)SCID) [MIM:601457]. SCID refers to a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-
      • Subcellular Location：
      • Nucleus .
      • Expression：
      • Cells of the B- and T-lymphocyte lineages.
      • Products Images
      • Western Blot analysis using RAG-2 Monoclonal Antibody against RAG2-hIgGFc transfected HEK293 (1)cell lysate.

      Attributes

      • Code：
      • YM0550
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
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