• Target：
• Pax-4

• Fields：
• >>Maturity onset diabetes of the young

• Gene Name：
• PAX4

• Protein Name：
• Paired box protein Pax-4

• Human Gene Id：
• 5078

• Human Swiss Prot No：
• O43316

• Mouse Swiss Prot No：
• P32115

• Immunogen：
• Purified recombinant fragment of human Pax-4 expressed in E. Coli.

• Specificity：
• Pax-4 Monoclonal Antibody detects endogenous levels of Pax-4 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PAX4;Paired box protein Pax-4

• Molecular Weight(Da)：
• 38kD

• References：
• 1. PLoS One. 2008 Mar 12;3(3):e1783.
  2. Diabetes Res Clin Pract. 2008 Sep;81(3):365-9.

• Background：
• This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The paired box 4 gene is involved in pancreatic islet development and mouse studies have demonstrated a role for this gene in differentiation of insulin-producing beta cells. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in PAX4 are a cause of noninsulin-dependent diabetes mellitus (NIDDM) [MIM:125853]; also known as diabetes mellitus type 2 or maturity-onset diabetes. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.,disease:Defects in PAX4 are the cause of maturity-onset diabetes of the young type 9 (MODY9) [MIM:612225]. MODY [MIM:606391] is a form of diabetes mellitus characterized by an autosomal dominant mode of inheritance, age of onset of 25 years or younger and a primary defect in insulin secretion.,disease:Genetic variations in PAX4 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsi

• Subcellular Location：
• Nucleus.

• Expression：
• Colon,Insulinoma,PCR rescued clones,Placenta,

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