Axl Monoclonal Antibody

    • Catalog No.：YM0055
    • Applications：WB;IF;ELISA
    • Reactivity：Human
      • Target：
      • Axl
      • Fields：
      • >>EGFR tyrosine kinase inhibitor resistance
      • Gene Name：
      • AXL UFO
      • Protein Name：
      • Tyrosine-protein kinase receptor UFO
      • Human Gene Id：
      • 558
      • Human Swiss Prot No：
      • P30530
      • Mouse Swiss Prot No：
      • Q00993
      • Immunogen：
      • Purified recombinant extracellular fragment of human Axl fused with hIgGFc tag expressed in HEK293 cell line.
      • Specificity：
      • Axl Monoclonal Antibody detects endogenous levels of Axl protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Monoclonal, Mouse
      • Dilution：
      • WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • Affinity purification
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • AXL;UFO;Tyrosine-protein kinase receptor UFO;AXL oncogene
      • Observed Band(KD)：
      • 130kD
      • References：
      • 1. Br J Cancer. 2006 May 22;94(10):1446-51.
        2. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5799-804.
      • Background：
      • The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013],
      • Function：
      • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia.,function:May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 2 fibronectin type-III domains.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Heterodimer and heterotetramer with GAS6.,tissue specificity:Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.,
      • Subcellular Location：
      • Cell membrane ; Single-pass type I membrane protein .
      • Expression：
      • Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
      • Products Images
      • Western Blot analysis using Axl Monoclonal Antibody against extracellular domain of human AXL (aa19-444).
      • Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using Axl Monoclonal Antibody (green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.

      Attributes

      • Code：
      • YM0055
      • Size
      • 50μL / 100μL / 200μL
      • Price$：
      • 210 / 350 / 600
      • Delivery：
      • 2024-11-30
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