• Gene Name：
• AGER

• Protein Name：
• Advanced glycosylation end product-specific receptor

• Human Gene Id：
• 177

• Human Swiss Prot No：
• Q15109

• Mouse Swiss Prot No：
• Q62151

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• AGER;RAGE;Advanced glycosylation end product-specific receptor;Receptor for advanced glycosylation end products

• Detection Method：
• Colorimetric

• Background：
• function:Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Receptor for amyloid beta peptide.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Endothelial cells.,

• Function：
• defense response, inflammatory response, cell surface receptor linked signal transduction, intracellular signaling cascade, protein kinase cascade, JAK-STAT cascade, aging, positive regulation of cell proliferation, response to wounding, regulation of response to external stimulus, positive regulation of response to external stimulus, regulation of locomotion, positive regulation of locomotion, regulation of cell proliferation, positive regulation of behavior, positive regulation of response to stimulus, regulation of smooth muscle cell proliferation, positive regulation of smooth muscle cell proliferation, regulation of behavior, regulation of chemotaxis, positive regulation of chemotaxis, regulation of positive chemotaxis, positive regulation of positive chemotaxis, induction of positive chemotaxis,

• Subcellular Location：
• [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 10]: Cell membrane ; Single-pass type I membrane protein .

• Expression：
• Endothelial cells.

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