• Gene Name：
• F3

• Protein Name：
• Tissue factor

• Human Gene Id：
• 2152

• Human Swiss Prot No：
• P13726

• Mouse Swiss Prot No：
• P20352

• Specificity：
• Sample Type for Cell Culture Supernates, Cell lysates, Tissue Lysates, Serum, EDTA Plasma, Heparin Plasma

• Storage Stability：
• 2-8°C/6 months

• Other Name：
• F3;Tissue factor;TF;Coagulation factor III;Thromboplastin;CD antigen CD142

• Detection Method：
• Colorimetric

• Background：
• function:Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.,induction:TF expression is highly dependent upon cell type. TF can also be induced by the inflammatory mediators interleukin 1 and TNF, as well as by endotoxin, to appear on monocytes and vascular endothelial cells as a component of cellular immune response.,online information:The Singapore human mutation and polymorphism database,online information:Tissue factor entry,similarity:Belongs to the tissue factor family.,

• Function：
• regulation of endothelial cell proliferation, positive regulation of endothelial cell proliferation, acute inflammatory response, activation of plasma proteins involved in acute inflammatory response, activation of blood coagulation via clotting cascade, proteolysis, apoptosis, anti-apoptosis, activation of caspase activity, defense response, inflammatory response, blood coagulation, blood coagulation, extrinsic pathway, hemostasis, cell death, positive regulation of cell proliferation, response to wounding, positive regulation of signal transduction, regulation of protein kinase cascade,regulation of platelet-derived growth factor receptor signaling pathway, positive regulation of platelet-derived growth factor receptor signaling pathway, positive regulation of cell communication, positive regulation of protein kinase cascade, regulation of cell death, positive regulation of peptidase a

• Subcellular Location：
• [Isoform 1]: Membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .

• Expression：
• Lung, placenta and pancreas.

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