AGRP rabbit pAb
- Catalog No.:YT7889
- Applications:WB;ELISA
- Reactivity:Human;Mouse
- Target:
- AGRP
- Fields:
- >>Adipocytokine signaling pathway
- Gene Name:
- AGRP AGRT ART
- Protein Name:
- AGRP
- Human Gene Id:
- 181
- Human Swiss Prot No:
- O00253
- Mouse Gene Id:
- 11604
- Mouse Swiss Prot No:
- P56473
- Immunogen:
- Synthesized peptide derived from human AGRP
- Specificity:
- This antibody detects endogenous levels of Human,Mouse AGRP
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- WB 1:1000-2000 ELISA 1:5000-20000
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- Agouti-related protein
- Molecular Weight(Da):
- 15kD
- Background:
- disease:Defects in AGRP may be a cause of autosomal dominant obesity [MIM:601665].,domain:The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.,function:Plays a role in weight homeostasis. May play a role in the regulation of melanocortin receptors within the hypothalamus and adrenal gland, and therefore in the central control of feeding.,similarity:Contains 1 agouti domain.,tissue specificity:Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.,
- Function:
- cell surface receptor linked signal transduction, G-protein coupled receptor protein signaling pathway, neuropeptide signaling pathway, intracellular signaling cascade, behavior, feeding behavior, adult feeding behavior, response to endogenous stimulus, response to hormone stimulus, hormone-mediated signaling, response to organic substance,adult behavior, cellular response to hormone stimulus, eating behavior,
- Subcellular Location:
- Secreted . Golgi apparatus lumen .
- Expression:
- Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
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