• Target：
• RBP

• Gene Name：
• RBP4 PRO2222

• Protein Name：
• RBP

• Human Gene Id：
• 5950

• Human Swiss Prot No：
• P02753

• Mouse Gene Id：
• 19662

• Mouse Swiss Prot No：
• Q00724

• Rat Gene Id：
• 25703

• Rat Swiss Prot No：
• P04916

• Immunogen：
• Synthesized peptide derived from human RBP AA range: 11-60

• Specificity：
• This antibody detects endogenous levels of Human RBP

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Retinol-binding protein 4 (Plasma retinol-binding protein;PRBP;RBP) [Cleaved into: Plasma retinol-binding protein(1-182);Plasma retinol-binding protein(1-181);Plasma retinol-binding protein(1-179);Plasma retinol-binding protein(1-176)]

• Molecular Weight(Da)：
• 22kD

• Background：
• retinol binding protein 4(RBP4) Homo sapiens This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008],

• Function：
• disease:A deficiency of vitamin A blocks secretion of the binding protein post-translationally and results in defective delivery and supply of vitamin to the epidermal cells (a condition associated with a dermatosis).,disease:Defects in RBP4 are a cause of retinol-binding protein deficiency [MIM:180250]. This condition causes night vision problems. It produces a typical "fundus xerophthalmicus," featuring a progressed atrophy of the retinal pigment epithelium.,function:Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.,mass spectrometry: PubMed:12237133,mass spectrometry: PubMed:7666002,online information:Retina International's Scientific Newsletter,online information:Retinol-binding protein 4 entry,similarity:Belongs to the calycin superfamil

• Subcellular Location：
• Secreted .

• Expression：
• Detected in blood plasma and in urine (at protein level).

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