• Target：
• TRIM3

• Gene Name：
• TRIM3

• Protein Name：
• Tripartite motif-containing protein 3

• Human Gene Id：
• 10612

• Human Swiss Prot No：
• O75382

• Mouse Gene Id：
• 55992

• Mouse Swiss Prot No：
• Q9R1R2

• Rat Gene Id：
• 83616

• Rat Swiss Prot No：
• O70277

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TRIM3. AA range:1-50

• Specificity：
• TRIM3 Polyclonal Antibody detects endogenous levels of TRIM3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TRIM3;BERP;RNF22;RNF97;Tripartite motif-containing protein 3;Brain-expressed RING finger protein;RING finger protein 22;RING finger protein 97

• Observed Band(KD)：
• 81kD

• Background：
• The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008],

• Function：
• domain:The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 filamin repeat.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 6 NHL repeats.,subunit:Associates with myosin V and alpha-actinin-4 (ACTN4).,tissue specificity:Expressed in brain, heart, uterus and testis.,

• Subcellular Location：
• Cytoplasm . Early endosome . Golgi apparatus, trans-Golgi network . Cell projection, dendrite .

• Expression：
• Expressed in brain, heart, uterus and testis.

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