• Target：
• Translin

• Gene Name：
• TSN

• Protein Name：
• Translin

• Human Gene Id：
• 7247

• Human Swiss Prot No：
• Q15631

• Mouse Gene Id：
• 22099

• Mouse Swiss Prot No：
• Q62348

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TSN. AA range:101-150

• Specificity：
• Translin Polyclonal Antibody detects endogenous levels of Translin protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:40000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TSN;Translin;Component 3 of promoter of RISC;C3PO

• Observed Band(KD)：
• 26kD

• Background：
• This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012],

• Function：
• function:DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occuring at recombination hot spots.,similarity:Belongs to the translin family.,subunit:Forms a multimeric ring-shaped structure. Interacts with TSNAX.,

• Subcellular Location：
• Cytoplasm . Nucleus .

• Expression：
• Liver,Lung,

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