• Target：
• TMPRSS3

• Gene Name：
• TMPRSS3

• Protein Name：
• Transmembrane protease serine 3

• Human Gene Id：
• 64699

• Human Swiss Prot No：
• P57727

• Mouse Gene Id：
• 140765

• Mouse Swiss Prot No：
• Q8K1T0

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TMPRSS3. AA range:405-454

• Specificity：
• TMPRSS3 Polyclonal Antibody detects endogenous levels of TMPRSS3 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TMPRSS3;ECHOS1;TADG12;Transmembrane protease serine 3;Serine protease TADG-12;Tumor-associated differentially-expressed gene 12 protein

• Observed Band(KD)：
• 49kD

• Background：
• This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012],

• Function：
• disease:Defects in TMPRSS3 are a cause of non-syndromic sensorineural deafness autosomal recessive type 10 (DFNB10) [MIM:605316].,disease:Defects in TMPRSS3 are the cause of non-syndromic sensorineural deafness autosomal recessive type 8 (DFNB8) [MIM:601072]. DFNA8 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.,function:Probable protease. Seems to be capable of activating ENaC.,PTM:Undergoes autoproteolytic activation.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 LDL-receptor class A domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 1 SRCR domain.,tissue specificity:Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.,

• Subcellular Location：
• Endoplasmic reticulum membrane ; Single-pass type II membrane protein .

• Expression：
• Expressed in many tissues including fetal cochlea. Isoform T is found at increased levels in some carcinomas.

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