• Target：
• TM4SF1

• Gene Name：
• TM4SF1

• Protein Name：
• Transmembrane 4 L6 family member 1

• Human Gene Id：
• 4071

• Human Swiss Prot No：
• P30408

• Mouse Gene Id：
• 17112

• Mouse Swiss Prot No：
• Q64302

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human T4S1. AA range:1-50

• Specificity：
• TM4SF1 Polyclonal Antibody detects endogenous levels of TM4SF1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TM4SF1;M3S1;TAAL6;Transmembrane 4 L6 family member 1;Membrane component chromosome 3 surface marker 1;Tumor-associated antigen L6

• Molecular Weight(Da)：
• 22kD

• Background：
• The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008],

• Function：
• similarity:Belongs to the L6 tetraspanin family.,subunit:Present in high molecular weight complexes in tumor cells.,tissue specificity:Highly expressed on lung, breast, colon, and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.,

• Subcellular Location：
• Membrane; Multi-pass membrane protein. Colocalizes with SDCBP2 in the apical region of the cell (PubMed:11102519). .

• Expression：
• Highly expressed in lung, breast, colon and ovarian carcinomas. It is also present on some normal cells, endothelial cells in particular.

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