• Target：
• THC2

• Gene Name：
• MASTL

• Protein Name：
• Serine/threonine-protein kinase greatwall

• Human Gene Id：
• 84930

• Human Swiss Prot No：
• Q96GX5

• Mouse Gene Id：
• 67121

• Mouse Swiss Prot No：
• Q8C0P0

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human MASTL. AA range:821-870

• Specificity：
• THC2 Polyclonal Antibody detects endogenous levels of THC2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• MASTL;GW;GWL;THC2;Serine/threonine-protein kinase greatwall;GW;GWL;hGWL;Microtubule-associated serine/threonine-protein kinase-like;MAST-L

• Observed Band(KD)：
• 97kD

• Background：
• This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Feb 2010],

• Function：
• catalytic activity:ATP + a protein = ADP + a phosphoprotein.,disease:Defects in MASTL are the cause of thrombocytopenia type 2 (THC2) [MIM:188000]. Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting.,function:Putative serine/threonine kinase which may be involved in megakaryocyte differentiation.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,

• Subcellular Location：
• Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus . Cleavage furrow . During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. .

• Expression：
• Epithelium,Placenta,

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