• Target：
• TFIIH p44

• Fields：
• >>Basal transcription factors;>>Nucleotide excision repair;>>Viral carcinogenesis

• Gene Name：
• GTF2H2

• Protein Name：
• General transcription factor IIH subunit 2

• Human Gene Id：
• 2966

• Human Swiss Prot No：
• Q13888

• Mouse Gene Id：
• 23894

• Mouse Swiss Prot No：
• Q9JIB4

• Rat Gene Id：
• 294693

• Rat Swiss Prot No：
• A0JN27

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TF2H2. AA range:1-50

• Specificity：
• TFIIH p44 Polyclonal Antibody detects endogenous levels of TFIIH p44 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• GTF2H2;BTF2P44;General transcription factor IIH subunit 2;Basic transcription factor 2 44 kDa subunit;BTF2 p44;General transcription factor IIH polypeptide 2;TFIIH basal transcription factor complex p44 subunit

• Observed Band(KD)：
• 62kD

• Background：
• This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of t

• Function：
• alternative products:A number of isoforms may be produced. The isoforms may be also produced by incomplete gene duplication,function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.,function:Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.,similarity:Belongs to the GTF2H2 family.,similarity:Contains 1 VWFA domain.,subunit:One of the six subunits forming the core-TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3.,tissue specificity:Widely expressed, with higher express

• Subcellular Location：
• Nucleus .

• Expression：
• Widely expressed, with higher expression in skeletal muscle.

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