Tensin-1 Polyclonal Antibody

    • Catalog No.：YT4603
    • Applications：WB;ELISA
    • Reactivity：Human;Mouse
      • Target：
      • Tensin-1
      • Gene Name：
      • TNS1
      • Protein Name：
      • Tensin-1
      • Human Gene Id：
      • 7145
      • Human Swiss Prot No：
      • Q9HBL0
      • Immunogen：
      • The antiserum was produced against synthesized peptide derived from human Tensin-1. AA range:1273-1322
      • Specificity：
      • Tensin-1 Polyclonal Antibody detects endogenous levels of Tensin-1 protein.
      • Formulation：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source：
      • Polyclonal, Rabbit,IgG
      • Dilution：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • Purification：
      • The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
      • Concentration：
      • 1 mg/ml
      • Storage Stability：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name：
      • TNS1;TNS;Tensin-1
      • Observed Band(KD)：
      • 200kD
      • Background：
      • The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
      • Function：
      • function:May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.,PTM:Rapidly cleaved by calpain II.,PTM:Tyrosine phosphorylated.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subunit:Binds to actin filaments and interacts with phosphotyrosine-containing proteins. Interacts with STARD8.,tissue specificity:Ubiquitous.,
      • Subcellular Location：
      • Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
      • Expression：
      • Ubiquitous.
      • Products Images
      • Western Blot analysis of K562 cells using Tensin-1 Polyclonal Antibody
      • Western blot analysis of lysate from K562 cells, using Tensin-1 antibody.

      Attributes

      • Code：
      • YT4603
      • Size
      • 40μL / 100μL / 200μL
      • Price$：
      • 150 / 280 / 450
      • Delivery：
      • 2024-07-17
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