• Target：
• TBC1D3A/B/C

• Gene Name：
• TBC1D3

• Protein Name：
• TBC1 domain family member 3

• Human Gene Id：
• 414059/727735/84218/643947/414060/653380/654341/729873

• Human Swiss Prot No：
• Q8IZP1/A6NDS4/Q6IPX1

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TBC1D3. AA range:481-530

• Specificity：
• TBC1D3A/B/C Polyclonal Antibody detects endogenous levels of TBC1D3A/B/C protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:20000.. IF 1:50-200

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TBC1D3;PRC17;TBC1D3A;TBC1 domain family member 3;Prostate cancer gene 17 protein;Protein TRE17-alpha;Rab GTPase-activating protein PRC17;TBC1D3B;TBC1D3I;TBC1 domain family member 3B;TBC1D3C;TBC1D3D;TBC1 domain family member 3C

• Observed Band(KD)：
• 62kD

• Background：
• This gene represents one of a cluster of related genes found on chromosome 17. The proteins encoded by this gene family contain a TBC (Tre-2, Bub2p, and Cdc16p) domain and may be involved in GTPase signaling and vesicle trafficking. [provided by RefSeq, Apr 2014],

• Function：
• disease:May be involved in forms of prostate cancers.,function:Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11.,similarity:Contains 1 Rab-GAP TBC domain.,tissue specificity:Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.,tissue specificity:Expressed in pancreas, thymus and testis.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor . Associated with lipid rafts.

• Expression：
• Expressed in liver, skeletal muscle, kidney, pancreas, spleen, testis, ovary, small intestine and peripheral blood leukocytes. Overexpressed in prostate cancers.

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