Sox-12 Polyclonal Antibody
- Catalog No.:YT4368
- Applications:IHC;IF;ELISA
- Reactivity:Human;Mouse
- Target:
- Sox-12
- Gene Name:
- SOX12
- Protein Name:
- Transcription factor SOX-12
- Human Gene Id:
- 6666
- Human Swiss Prot No:
- O15370
- Mouse Gene Id:
- 20667
- Mouse Swiss Prot No:
- Q04890
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human SOX12. AA range:71-120
- Specificity:
- Sox-12 Polyclonal Antibody detects endogenous levels of Sox-12 protein.
- Formulation:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source:
- Polyclonal, Rabbit,IgG
- Dilution:
- IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Concentration:
- 1 mg/ml
- Storage Stability:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Other Name:
- SOX12;SOX22;Transcription factor SOX-12;Protein SOX-22
- Molecular Weight(Da):
- 34kD
- Background:
- Members of the SOX family of transcription factors are characterized by the presence of a DNA-binding high mobility group (HMG) domain, homologous to the HMG box of sex-determining region Y (SRY). Forming a subgroup of the HMG domain superfamily, SOX proteins have been implicated in cell fate decisions in a diverse range of developmental processes. SOX transcription factors have diverse tissue-specific expression patterns during early development and have been proposed to act as target-specific transcription factors and/or as chromatin structure regulatory elements. The protein encoded by this gene was identified as a SOX family member based on conserved domains, and its expression in various tissues suggests a role in both differentiation and maintenance of several cell types. [provided by RefSeq, Jan 2013],
- Function:
- function:Binds to the sequence 5'-AACAAT-3'.,similarity:Contains 1 HMG box DNA-binding domain.,tissue specificity:Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive.,
- Subcellular Location:
- Nucleus .
- Expression:
- Expressed most abundantly in the CNS (PubMed:9215677). Expressed in the heart, pancreas, thymus, testis and ovary (PubMed:9215677). Weakly expressed in brain, placenta, lung, liver, skeletal muscle, kidney, spleen, prostate, small intestine, colon, and peripheral blood lymphocytes (PubMed:9215677).
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- Products Images
- Immunohistochemistry analysis of paraffin-embedded human brain tissue, using SOX12 Antibody. The picture on the right is blocked with the synthesized peptide.