• Target：
• PMEPA1

• Gene Name：
• PMEPA1

• Protein Name：
• Transmembrane prostate androgen-induced protein

• Human Gene Id：
• 56937

• Human Swiss Prot No：
• Q969W9

• Mouse Swiss Prot No：
• Q9D7R2

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human TMEPA. AA range:101-150

• Specificity：
• PMEPA1 Polyclonal Antibody detects endogenous levels of PMEPA1 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PMEPA1;STAG1;TMEPAI;Transmembrane prostate androgen-induced protein;Solid tumor-associated 1 protein

• Observed Band(KD)：
• 37kD

• Background：
• This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011],

• Function：
• domain:The WW-binding motifs mediate interaction with NEDD4.,induction:By androgen.,similarity:Belongs to the PMEPA1 family.,subunit:Interacts with the WW domains of NEDD4.,tissue specificity:Highest expression in prostate. Also expressed in ovary.,

• Subcellular Location：
• Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.

• Expression：
• Highest expression in prostate. Also expressed in ovary.

Unraveling the immune landscape and therapeutic biomarker PMEPA1 for oxaliplatin resistance in colorectal cancer: A comprehensive approach BIOCHEMICAL PHARMACOLOGY Zhengguang Zhang WB,IHC Human,Mouse 1:1000 colorectal cancer (CRC) tissue,HCT116R cell-Xenograft HCT116 cell

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