• Target：
• pHyde

• Fields：
• >>p53 signaling pathway;>>Ferroptosis

• Gene Name：
• STEAP3

• Protein Name：
• Metalloreductase STEAP3

• Human Gene Id：
• 55240

• Human Swiss Prot No：
• Q658P3

• Mouse Gene Id：
• 68428

• Mouse Swiss Prot No：
• Q8CI59

• Rat Gene Id：
• 170824

• Rat Swiss Prot No：
• Q5RKL5

• Immunogen：
• The antiserum was produced against synthesized peptide derived from human STEA3. AA range:421-470

• Specificity：
• pHyde Polyclonal Antibody detects endogenous levels of pHyde protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• STEAP3;TSAP6;Metalloreductase STEAP3;Dudulin-2;Six-transmembrane epithelial antigen of prostate 3;Tumor suppressor-activated pathway protein 6;hTSAP6;pHyde;hpHyde

• Observed Band(KD)：
• 54kD

• Background：
• STEAP3 metalloreductase(STEAP3) Homo sapiens This gene encodes a multipass membrane protein that functions as an iron transporter. The encoded protein can reduce both iron (Fe3+) and copper (Cu2+) cations. This protein may mediate downstream responses to p53, including promoting apoptosis. Deficiency in this gene can cause anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015],

• Function：
• caution:Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).,cofactor:FAD.,function:Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.,induction:By p53/TP53.,similarity:Belongs to the STEAP family.,similarity:Contains 1 ferric oxidoreductase domain.,subcellular location:Localizes to vesicular-like structures at the plasma membrane and around the nucleus.,su

• Subcellular Location：
• Endosome membrane ; Multi-pass membrane protein . Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

• Expression：
• Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.

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