• Target：
• PC-PLD2

• Fields：
• >>Glycerophospholipid metabolism;>>Ether lipid metabolism;>>Metabolic pathways;>>Ras signaling pathway;>>cAMP signaling pathway;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Endocytosis;>>Fc gamma R-mediated phagocytosis;>>Glutamatergic synapse;>>GnRH signaling pathway;>>Parathyroid hormone synthesis, secretion and action;>>Pathways in cancer;>>Chemical carcinogenesis - reactive oxygen species;>>Pancreatic cancer;>>Choline metabolism in cancer

• Gene Name：
• PLD2

• Protein Name：
• Phospholipase D2

• Human Gene Id：
• 5338

• Human Swiss Prot No：
• O14939

• Mouse Gene Id：
• 18806

• Mouse Swiss Prot No：
• P97813

• Rat Gene Id：
• 25097

• Rat Swiss Prot No：
• P70498

• Immunogen：
• Synthesized peptide derived from PC-PLD2 . at AA range: 110-190

• Specificity：
• PC-PLD2 Polyclonal Antibody detects endogenous levels of PC-PLD2 protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300; ELISA 2000-20000

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• PLD2;Phospholipase D2;PLD 2;hPLD2;Choline phosphatase 2;PLD1C;Phosphatidylcholine-hydrolyzing phospholipase D2

• Observed Band(KD)：
• 106kD

• Background：
• The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011],

• Function：
• catalytic activity:A phosphatidylcholine + H(2)O = choline + a phosphatidate.,enzyme regulation:Stimulated by phosphatidylinositol 4,5-bisphosphate and activated by the ADP-ribosylation factor-1 (ARF-1).,function:May have a role in signal-induced cytoskeletal regulation and/or endocytosis.,online information:Phospholipase D entry,similarity:Belongs to the phospholipase D family.,similarity:Contains 1 PH domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 PLD phosphodiesterase domains.,subunit:Interacts with EGFR (By similarity). Interacts with PIP5K1A.,tissue specificity:Ubiquitous.,

• Subcellular Location：
• Cell membrane ; Lipid-anchor .

• Expression：
• Ubiquitous.

PLD2 deletion ameliorates sepsis-induced cardiomyopathy by suppressing cardiomyocyte pyroptosis via the NLRP3/caspase 1/GSDMD pathway INFLAMMATION RESEARCH Li Jun WB Rat,Mouse 1:1000 heart tissue H9C2 cardiomyocytes

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