• Target：
• LAB

• Gene Name：
• LAT2 LAB NTAL WBS15 WBSCR15 WBSCR5 HSPC046

• Protein Name：
• LAB (Phospho-Tyr136)

• Human Gene Id：
• 7462

• Human Swiss Prot No：
• Q9GZY6

• Mouse Gene Id：
• 56743

• Mouse Swiss Prot No：
• Q9JHL0

• Rat Gene Id：
• 317676

• Rat Swiss Prot No：
• Q8CGL2

• Immunogen：
• Synthesized peptide derived from human LAB (Phospho-Tyr136)

• Specificity：
• This antibody detects endogenous levels of LAB (Phospho-Tyr136) at Human, Mouse,Rat

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Linker for activation of T-cells family member 2 (Linker for activation of B-cells) (Membrane-associated adapter molecule) (Non-T-cell activation linker) (Williams-Beuren syndrome chromosomal region 15 protein) (Williams-Beuren syndrome chromosomal region 5 protein)

• Observed Band(KD)：
• 30kD

• Background：
• This gene is one of the contiguous genes at 7q11.23 commonly deleted in Williams syndrome, a multisystem developmental disorder. This gene consists of at least 14 exons, and its alternative splicing generates 3 transcript variants, all encoding the same protein. [provided by RefSeq, Jul 2008],

• Function：
• disease:Defects in LAT2 may be a cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS) [MIM:194050]. WBS is a rare developmental disorder. It is a contiguous gene deletion syndrome involving genes from chromosome band 7q11.23.,function:Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.,PTM:May be polyubiquitinated.,PTM:Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells; which induces the recruitment of GRB2.,s

• Subcellular Location：
• Cell membrane ; Single-pass type III membrane protein . Present in lipid rafts.

• Expression：
• Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

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