MLKL Phospho ser345 rabbit pAb

  • Catalog No.：YP1710
  • Applications：WB
  • Reactivity：Human
    • Target：
    • MLKL
    • Fields：
    • >>Necroptosis;>>TNF signaling pathway;>>Salmonella infection
    • Gene Name：
    • MLKL
    • Protein Name：
    • MLKL Phospho-ser345
    • Human Swiss Prot No：
    • Q8NB16
    • Mouse Swiss Prot No：
    • Q9D2Y4
    • Immunogen：
    • Synthesized peptide derived from human MLKL Phospho-ser345
    • Specificity：
    • This antibody detects endogenous levels of MLKL Phospho-ser345 at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Mixed lineage kinase domain-like protein
    • Molecular Weight(Da)：
    • 52kD
    • Background：
    • This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
    • Function：
    • domain:The protein kinase domain is predicted to be catalytically inactive.,similarity:Belongs to the protein kinase superfamily.,similarity:Contains 1 protein kinase domain.,
    • Subcellular Location：
    • Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity). .
    • Expression：
    • Chondrocyte,Leukocyte,Lymph node,

    Attributes

    • Code：
    • YP1710
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-12-09
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