BLK (Phospho Tyr389) rabbit pAb

  • Catalog No.：YP1695
  • Applications：WB
  • Reactivity：Human;Mouse;Rat
    • Target：
    • BLK
    • Gene Name：
    • BLK
    • Protein Name：
    • BLK (Phospho-Tyr389)
    • Human Gene Id：
    • 640
    • Human Swiss Prot No：
    • P51451
    • Mouse Swiss Prot No：
    • P16277
    • Immunogen：
    • Synthesized peptide derived from human BLK (Phospho-Tyr389)
    • Specificity：
    • This antibody detects endogenous levels of BLK (Phospho-Tyr389) at Human, Mouse,Rat
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:500-2000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)
    • Molecular Weight(Da)：
    • 56kD
    • Background：
    • This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010],
    • Function：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:May function in a signal transduction pathway that is restricted to B-lymphoid cells.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,
    • Subcellular Location：
    • Cell membrane ; Lipid-anchor . Present and active in lipid rafts. Membrane location is required for the phosphorylation of CD79A and CD79B (By similarity). .
    • Expression：
    • Expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.

    Attributes

    • Code：
    • YP1695
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-12-09
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