ROS (Phospho Tyr2114) rabbit pAb

  • Catalog No.：YP1613
  • Applications：WB;ELISA
  • Reactivity：Human;Mouse;Rat
    • Target：
    • ROS1
    • Gene Name：
    • ROS1 MCF3 ROS
    • Protein Name：
    • ROS (Phospho Tyr2114)
    • Human Gene Id：
    • 6098
    • Human Swiss Prot No：
    • P08922
    • Mouse Swiss Prot No：
    • Q78DX7
    • Immunogen：
    • Synthesized peptide derived from human ROS (Phospho Tyr2114)
    • Specificity：
    • This antibody detects endogenous levels of Human,Mouse,Rat ROS (Phospho Tyr2114)
    • Formulation：
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source：
    • Polyclonal, Rabbit,IgG
    • Dilution：
    • WB 1:1000-2000 ELISA 1:5000-20000
    • Purification：
    • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
    • Concentration：
    • 1 mg/ml
    • Storage Stability：
    • -15°C to -25°C/1 year(Do not lower than -25°C)
    • Other Name：
    • Proto-oncogene tyrosine-protein kinase ROS (EC 2.7.10.1;Proto-oncogene c-Ros;Proto-oncogene c-Ros-1;Receptor tyrosine kinase c-ros oncogene 1;c-Ros receptor tyrosine kinase)
    • Observed Band(KD)：
    • 258kD
    • Background：
    • This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008],
    • Function：
    • catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:A chromosomal aberration involving ROS1 is found in glioblastoma multiform (GBM). An homozygous deletion in chromosome 6q21 results in expression of a GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity.,function:This is probably a cell growth or differentiation factor receptor with a tyrosine-protein kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 9 fibronectin type-III domains.,
    • Subcellular Location：
    • Cell membrane ; Single-pass type I membrane protein .
    • Expression：
    • Expressed in brain. Expression is increased in primary gliomas.

    Attributes

    • Code：
    • YP1613
    • Size
    • 50μL / 100μL / 200μL
    • Price$：
    • 190 / 340 / 600
    • Delivery：
    • 2024-11-25
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