Rictor (Phospho Thr1135) rabbit pAb

    • Catalog No.:YP1466
    • Applications:WB;IHC
    • Reactivity:Human;Mouse
      • Target:
      • Rictor
      • Fields:
      • >>mTOR signaling pathway
      • Gene Name:
      • RICTOR KIAA1999
      • Protein Name:
      • Rictor (Thr1135)
      • Human Swiss Prot No:
      • Q6R327
      • Mouse Swiss Prot No:
      • Q6QI06
      • Immunogen:
      • Synthesized phosho peptide around human Rictor (Thr1135)
      • Specificity:
      • This antibody detects endogenous levels of Human Mouse Rictor (phospho-Thr1135)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC-p 1:50-300
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3)
      • Observed Band(KD):
      • 190kD
      • Background:
      • RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008],
      • Function:
      • function:Plays an essential role in embryonic growth and development (By similarity). Part of the TORC2 complex which plays a critical role in AKT1 'Ser-473' phosphorylation, and may modulate the phosphorylation of PKCA and regulate actin cytoskeleton organization.,similarity:Belongs to the pianissimo family.,subunit:Forms part of the target of rapamycin 2 complex (TORC2) comprised of FRAP1, LST8, PROTOR1, RICTOR and MAPKAP1. TORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to FRAP1 and PROTOR1 within the TORC2 complex. May interact with PROTOR2.,
      • Subcellular Location:
      • cytosol,TORC2 complex,
      • Expression:
      • Amygdala,Brain,Epithelium,Lymph,
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).