• Target：
• Tensin-2

• Gene Name：
• TENC1

• Protein Name：
• Tensin-like C1 domain-containing phosphatase

• Human Gene Id：
• 23371

• Human Swiss Prot No：
• Q63HR2

• Mouse Gene Id：
• 209039

• Mouse Swiss Prot No：
• Q8CGB6

• Immunogen：
• Synthesized phospho-peptide around the phosphorylation site of human Tensin-2 (phospho Tyr483)

• Specificity：
• Phospho-Tensin-2 (Y483) Polyclonal Antibody detects endogenous levels of Tensin-2 protein only when phosphorylated at Y483.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• TENC1;KIAA1075;TNS2;Tensin-like C1 domain-containing phosphatase;C1 domain-containing phosphatase and tensin homolog;C1-TEN;Tensin-2

• Observed Band(KD)：
• 152kD

• Background：
• The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008],

• Function：
• function:Regulates cell motility and proliferation. May have phosphatase activity. Reduces AKT1 phosphorylation. Lowers AKT1 kinase activity and interferes with AKT1 signaling.,similarity:Contains 1 C2 tensin-type domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 phosphatase tensin-type domain.,similarity:Contains 1 SH2 domain.,subcellular location:Detected at the end of actin stress fibers.,subunit:Interacts with AXL.,tissue specificity:Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.,

• Subcellular Location：
• Cell junction, focal adhesion . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Detected at the end of actin stress fibers. Detected in cytoplasmic punctate bodies (PubMed:22019427). .

• Expression：
• Detected in heart, kidney, brain, thymus, spleen, liver, placenta, lung, skeletal muscle and small intestine.

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