S100 (ABT-S100B) mouse mAb

    • Catalog No.:YM6669
    • Applications:IHC-p
    • Reactivity:Human
    • Description
    • Gene Name:
    • S100B
    • Protein Name:
    • S100
    • Human Gene Id:
    • 6285
    • Human Swiss Prot No:
    • P04271
    • Immunogen:
    • Synthesized peptide derived from human S100
    • Specificity:
    • This antibody detects endogenous levels of human S100
    • Formulation:
    • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
    • Source:
    • Mouse/IgG1, Kappa
    • Dilution:
    • IHC-p 1:100-500
    • Purification:
    • The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
    • Concentration:
    • 1 mg/ml
    • Storage Stability:
    • -20°C/1 year
    • Background:
    • The protein encoded by S100B (S100 calcium binding protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of S100B have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.
    • Function:
    • cell morphogenesis, cell morphogenesis involved in differentiation, axonogenesis, behavior, learning or memory, cell proliferation, cell projection organization, neuron differentiation, neuron projection development, cellular component morphogenesis, cell part morphogenesis, neuron development, cell morphogenesis involved in neuron differentiation,neuron projection morphogenesis, cell projection morphogenesis, neurological system process, cognition,
    • Products Images
    • Immunohistochemical analysis of paraffin-embedded Malignant melanoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).
    • Immunohistochemical analysis of paraffin-embedded Malignant melanoma. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citrate buffer of pH6.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 30min).