• Target：
• TudorSN

• Fields：
• >>Viral carcinogenesis

• Gene Name：
• SND1

• Protein Name：
• Staphylococcal nuclease domain-containing protein 1

• Human Gene Id：
• 27044

• Human Swiss Prot No：
• Q7KZF4

• Mouse Swiss Prot No：
• Q78PY7

• Immunogen：
• Purified recombinant fragment of TudorSN (aa361-485) expressed in E. Coli.

• Specificity：
• TudorSN Monoclonal Antibody detects endogenous levels of TudorSN protein.

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Monoclonal, Mouse

• Dilution：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• Purification：
• Affinity purification

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• SND1;TDRD11;Staphylococcal nuclease domain-containing protein 1;100 kDa coactivator;EBNA2 coactivator p100;Tudor domain-containing protein 11;p100 co-activator

• Molecular Weight(Da)：
• 102kD

• References：
• 1. J Gen Virol. 2003 Sep;84(Pt 9):2317-22.
  2. Biochim Biophys Acta. 2005 Jan 11;1681(2-3):126-33.

• Background：
• This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016],

• Function：
• function:Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2).,PTM:Phosphorylated by PIM1 in vitro.,sequence caution:The frameshift leads to wrong initation.,similarity:Contains 1 Tudor domain.,similarity:Contains 4 TNase-like domains.,subcellular location:In IL-4 stimulated cells colocalizes with STAT6 in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Binds to acidic transactivation domain of EBNA2. Interacts with EAV NSP1. Interacts with GTF2E1 and GTF2E2. Forms a ternary complex with STAT6 and POLR2A. Interacts with STAT5.,tissue specificity:Ubiquitously expressed.,

• Subcellular Location：
• Cytoplasm . Nucleus . Melanosome . In IL-4 stimulated cells colocalizes with STAT6 in the nucleus (PubMed:12234934). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .

• Expression：
• Ubiquitously expressed.

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