MyoD (Acetyl Lys99/K102) rabbit pAb

    • Catalog No.:YK0160
    • Applications:WB;IHC
    • Reactivity:Human;Rat;Mouse;
      • Target:
      • MyoD
      • Fields:
      • >>Spinocerebellar ataxia
      • Gene Name:
      • MYOD1 BHLHC1 MYF3 MYOD
      • Protein Name:
      • MyoD (Acetyl Lys99/K102)
      • Human Gene Id:
      • 4654
      • Human Swiss Prot No:
      • P15172
      • Mouse Swiss Prot No:
      • P10085
      • Immunogen:
      • Synthesized peptide derived from human MyoD (Acetyl Lys99/K102)
      • Specificity:
      • This antibody detects endogenous levels of Human MyoD (Acetyl Lys99/K102)
      • Formulation:
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • Source:
      • Polyclonal, Rabbit,IgG
      • Dilution:
      • WB 1:500-2000;IHC 1:50-300
      • Purification:
      • The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
      • Concentration:
      • 1 mg/ml
      • Storage Stability:
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • Other Name:
      • Myoblast determination protein 1 (Class C basic helix-loop-helix protein 1;bHLHc1;Myogenic factor 3;Myf-3)
      • Observed Band(KD):
      • 69kD
      • Background:
      • This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis. [provided by RefSeq, Jul 2008],
      • Function:
      • function:Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins.,online information:MyoD entry,PTM:Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function.,PTM:Ubiquitinated on the N-terminus; which is required for proteasomal degradation.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1.,
      • Subcellular Location:
      • Nucleus.
      • Products Images
      • Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).