• Target：
• MMP-19

• Gene Name：
• MMP19 MMP18 RASI

• Protein Name：
• MMP19 (Cleaved-Tyr98)

• Human Gene Id：
• 4327

• Human Swiss Prot No：
• Q99542

• Mouse Gene Id：
• 58223

• Mouse Swiss Prot No：
• Q9JHI0

• Immunogen：
• Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)

• Specificity：
• This antibody detects endogenous levels of Human,Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 )

• Formulation：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Source：
• Polyclonal, Rabbit,IgG

• Dilution：
• WB 1:500-2000;IHC 1:50-300

• Purification：
• The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

• Concentration：
• 1 mg/ml

• Storage Stability：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• Other Name：
• Matrix metalloproteinase-19 (MMP-19;EC 3.4.24.-;Matrix metalloproteinase RASI;Matrix metalloproteinase-18;MMP-18)

• Observed Band(KD)：
• 45 55kD

• Background：
• alternative products:Additional isoforms seem to exist,catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.,function:Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.,PTM:Activated by autolytic cleavage after Lys-97.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.,

• Function：
• angiogenesis, blood vessel development, vasculature development, proteolysis, collagen catabolic process, collagen metabolic process, multicellular organismal metabolic process, multicellular organismal catabolic process, multicellular organismal macromolecule metabolic process, blood vessel morphogenesis,

• Subcellular Location：
• Secreted, extracellular space, extracellular matrix .

• Expression：
• Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients (PubMed:8920941).

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